Multiple autoantigen mimotopes of infectious agents induce autoimmune arthritis and uveitis in lewis rats.
نویسندگان
چکیده
We found multimolecular antigenic mimicry of arthritogenic autoantigens and peptides from several other "self" or foreign antigens sharing amino acid sequence homologies. Many of these new mimotopes induced arthritis and/or uveitis upon immunization in Lewis rats, indicating a role for multiple antigens in the initiation of a certain autoimmune disease.
منابع مشابه
Autoimmune uveitis induced by molecular mimicry of peptides from rotavirus, bovine casein and retinal S-antigen.
Antigenic mimicry of infectious agents and autoantigens is a proposed pathomechanism for autoimmune diseases. Here, we describe antigenic mimicry of a peptide from rotavirus, a nutritional protein from bovine milk (alphas2-casein) and a peptide thereof as well as a highly pathogenic peptide from retinal S-antigen (PDSAg), a major autoantigen in experimental autoimmune uveitis in Lewis rats. Imm...
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عنوان ژورنال:
- Clinical and diagnostic laboratory immunology
دوره 12 5 شماره
صفحات -
تاریخ انتشار 2005